10/28/2022 0 Comments Fessenden kimia organik jilid 2 pdfPreet, R., Mohapatra, M., Das, D., Satapathy, S.R., Choudhuri, T., Wyatt, M.D.,Kundu, C.N., 2012a. Quinacrine-mediated autophagy and apoptosis in colon cancer cellsis through a p53- and p21-dependent mechanism. Mohapatra, P., Preet, R., Das, D., Satapathy, S.R., Choudhuri, T., Wyatt, M.D., Kundu,C.N., 2012. Discipline of Medical Biochemistry, School of Laboratory Medicine and Medical Sciences, JPB. Mfan, S., Anand, K., Anandakumar, S., Singh, S., Chuturgoon, A. L., (1982), Brine shrimp:a convenient general bioassay foractive plant constituents. Lead profiling Lead- and drug-like compounds : the rule-of-five revolution, 337–341. European Journal of Medicinal Chemistry, 66, 355–363. European Journal of Medicinal Chemistry Antiparasitic hybrids of Cinchona alkaloids and bile acids. Leverrier, A., Bero, J., Frédérich, M., Quetin-leclercq, J., & Palermo, J. Enzymes involved in the bioconversion of ester-based prodrugs. Bioactive cinchona alkaloids from Remijia peruviana. Lastenia RM,Wilfredo RM, Matias R, RafaelMD, Concepcion DI, Guadano A, Azucena GC. Influence of Peripheral Groups on the Physical and Chemical Behavior of Cinchona Alkaloids, 11696– Anti-malarials are anti-cancers and vice versa - One arrow two sparrows. Synthesis and Biological Activity of Fatty Acid Derivatives of Quinine Synthesis and Biological Activity of Fatty Acid Derivatives of Quinine, 8451(October). N., Shimizu, S., Kim, S., Wataya, Y., Aba, N. Kementrian Kesehatan RI Pusat Data dan Informasi Kesehatan. Brain Research.Brain Research Reviews, 35(2), 161–204.įessenden, R., & Fessenden, J. Anticancer drug resistance in primary human brain tumors. Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist. Quinine, an old anti-malarial drug in a modernworld: role in the treatment of malaria. It was proved that higher lipophilicity could increase pharmacology activityĪchan, J., Talisuna, A.O., Erhart, A., Yeka, A., Tibenderana, J.K., Baliraine, F.N., Rosen-thal, P.J., D’Alessandro, U., 2011. BSLT result showed that cinchonidine isobutyrate ester had LC 50 value of 75.16 ppm which was more toxic than cinchonidine that had LC 50 value of 99.2 ppm. Ester cinchonidine isobutyrate is gelatinous and colourless with yield of 21,77%. The product is identified by ESI-MS, FT-IR, 1H-NMR, dan 13C-NMR. Isobutyric acid is a type of short chained fatty acid that usually acts as an anticancer prodrugs. The esterification process used DMAP as a catalyst, DCC as an activator, and isobutyric acid as a carboxilyc acid. Higher lipophilicity makes it easier for the compund to pass through cell membrane. Synthesized ester was aimed to gain higher lipophilicity. Cinchonidine is predicted to have anticancer activity. Cinchonidine, a compound that has quinoline rings and quiniclidine ring, is a quinine analogue and stereoisomer of cinchonine. W.This research was aimed to synthesize cinchonidine isobutyrate ester and conduct a preliminary assay for anticancer agent using cytotoxicity assay to Artemia salina Leach larva, or also known as brine shrimp lethality test (BSLT). L., 1976., Organic Chemistry, 2 nd edition, Worth Publishers, Inc., New York A., 1978, Vogel’s Textbook of Practical Organic Chemistry, 5 th edition, The English Language Book Society and Longman, London N., 1981, Organic Chemistry, 3 rd edition, university Publication, Taiwan J., 1983, Rancidity in Food, Applied Science Publishers LTD, England Hilditch, T.P., 1949, Industrial Chemistry of Fats and Waxes, 3 rd edition, Bailliere, Tindall and Cox, London S., 1947, Fatty Acid, 1 st, Interscience Publishers, Inc., New York Ketaren, S., 1986, Pengantar Teknologi Minyak dan Lemak, edisi I, Penerbit Universitas Indonesia, Jakarta Surdia, 1992, Kimia Organik, jilid II, Erlangga, Jakarta S., 1986, Organic Chemistry, diterjemahkan oleh Pudjo Atmoko, A.
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